Updated: Sep 1, 2021
Regenerative Medicine Options for Chronic Musculoskeletal Conditions: A Review of the Literature
Sean W. Mulvaney, MD1; Paul Tortland, DO2; Brian Shiple, DO3; Kamisha Curtis, MPH4
1 Associate Professor of Medicine, Uniformed Services University, Bethesda, MD
2 FAOASM, Associate Clinical Professor of Medicine, University of Connecticut, Farmington, CT
3 CAQSM, RMSK, ARDMS; The Center for Sports Medicine & Wellness, Glen Mills, PA
4 Regenerative and Orthopedic Sports Medicine, Annapolis, MD
Regenerative medicine as applied to musculoskeletal injuries is a term used to describe a growing field of musculoskeletal medicine that concentrates on evidence-based treatments that focus on and augment the body’s endogenous repair capabilities. These treatments are targeted at the specific injury site or region of injury by the precise application of autologous, allogeneic or proliferative agents.
Focusing on the repair of chronic musculoskeletal injuries, this paper will discuss both background and emerging theories in regenerative medicine, as well as specifically address developments in the clinically-relevant literature on specific treatments including: prolotherapy, platelet- rich plasma, autologous mesenchymal stems cells, alpha 2 macroglobin, and human tissue- derived allograft products.