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Knee Osteoarthritis? Study shows P-PRP 430% Superior to Saline!

Intra‐articular injections of platelet‐rich plasma decrease pain and improve functional outcomes than sham saline in patients with knee osteoarthritis Jiabao Chu1,7 · Weifeng Duan1 · Ziqiang Yu2,3 · Tao Tao4 · Jie Xu5 · Qianli Ma6 · Lingying Zhao2,3 · Jiong Jiong Guo1,2 Received: 14 October 2021 / Accepted: 10 January 2022 © The Author(s) under exclusive licence to European Society of Sports Traumatology, Knee Surgery, Arthroscopy (ESSKA) 2022

Following is the summary of the above article:

This controlled double-blind study used diverse tests to determine the efficacy of P-PRP versus saline on knee osteoarthritis. The tests used to measure the clinical results of each treatment were the WOMAC Osteoarthritis Index to measure pain, range of motion, and knee function; IKDC test to measure pain, biochemical markers in the joint, and cartilage; and MRI scans to assess cartilage loss. These tests were performed to establish a baseline and then at 3, 6, 12, 24, and 60 months following the procedures. This study demonstrated that there were significantly better clinical results 3 months after both types of procedure. Following the 3 month mark, the saline group showed no further improvement, in fact they declined. Whereas the PRP group showed significant improvement at least 24 months and up to 48 months. The PRP group also demonstrated less cartilage loss with almost 50% less cartilage loss as compared to the saline group. At 6 months post-procedure the saline group had the same inflammatory factors that they did before the procedure, while the PRP group saw reduced inflammatory factors. This study demonstrated that overall PRP was a whopping 430% more effective than saline at treating knee osteoarthritis.

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